abstract：:The present report describes a patient with polycythemia vera who developed a severe arterial and venous thrombosis caused by systemically administered heparin. An immunologic implication has been proposed as pathophysiological mechanism of this heparin-associated thrombocytopenia and thrombosis syndrome. It is sugges...

journal_title：Acta haematologica

authors： Garcia S,Cervero A,Sanchez M,Colomina P

更新日期：1991-01-01 00:00:00

abstract：:Agranulocytosis is a rare side effect of phenytoin treatment. We describe the case of an elderly man who developed agranulocytosis 2 weeks following initiation of phenytoin treatment, on no cytotoxic drugs or any other medications except decadron. The white blood cell count was 300/mm3 with absent granulocytes. The li...

journal_title：Acta haematologica

authors： Sharafuddin MJ,Spanheimer RG,McClune GL

更新日期：1991-01-01 00:00:00

abstract：:The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the cerebrospinal fluid from 14 infants and children with meningitis and 6 patients who suffered other diseases besides meningitis was measured by our sensitive enzyme linked immunosorbent assay for GM-CSF. The minimal detection level of GM-CSF ...

journal_title：Acta haematologica

authors： Shimoda K,Okamura S,Omori F,Mizuno Y,Hara T,Aoki T,Akeda H,Ueda K,Niho Y

更新日期：1991-01-01 00:00:00

abstract：:A 69-year-old man with a rare case of lymphoma-type alpha-chain disease was admitted to the hospital with marked cervical and inguinal lymph node swelling. Lymph node biopsy showed marked infiltration of plasma cells, plasmacytoid cells and immunoblastoid cells, alone or in combination. Immunoelectrophoresis and immun...

journal_title：Acta haematologica

authors： Itoh Y,Ohtaki H,Ono T,Mori N,Kawaoi A,Kawai T

更新日期：1991-01-01 00:00:00

abstract：:To test whether anti-idiotypic immunoregulation of factor VIII(FVIII)-inhibiting antibodies could be feasible in hemophiliacs, we assayed the minimal number and range of immunogenic, functional FVIII epitopes to which a series of murine anti-FVIII monoclonal antibodies (MAb) were directed. Rabbit anti-idiotypic sera t...

journal_title：Acta haematologica

authors： Tiarks CY,Humphreys RE,Pechet L

更新日期：1990-01-01 00:00:00

abstract：:96 consecutive acute myelogenous leukemia (AML) patients were analyzed retrospectively with regard to the regimen used for remission induction. 35 patients received daunorubicin for 3 days, cytosine arabinoside and 6-thioguanine for 7 days. 61 were treated with the same regimen but 6-thioguanine was replaced by etopos...

journal_title：Acta haematologica

authors： Leoni F,Ciolli S,Patriarchi S,Morfini M,Rossi Ferrini P

更新日期：1990-01-01 00:00:00

abstract：:A hemophilia B patient, seropositive for HIV antibodies since 1984, came to us in March 1989 with a severe necrotizing lesion of the nose. It was an erythematous lesion and looked like rhinophyma. Microbiological examination of the skin biopsy showed the presence of Cryptococcus neoformans. At the time of the study, t...

journal_title：Acta haematologica

authors： Mares M,Sartori MT,Carretta M,Bertaggia A,Girolami A

更新日期：1990-01-01 00:00:00

abstract：:Human urinary erythropoietin has been purified to homogeneity. The seven-step procedure yielded a preparation with a potency of 225,000 U/mg protein. SDS-polyacrylamide gel electrophoretic analysis of the purified hormone revealed a single protein band with a molecular weight of about 35,000 that migrated with the bio...

journal_title：Acta haematologica

authors： Matsushita J,Kawakita M,Shibuya K,Koishihara Y,Sakaguchi M,Takatsuki A

更新日期：1990-01-01 00:00:00

abstract：:A 69-year-old woman with typical thrombotic thrombocytopenic purpura is reported, who was treated successfully by plasma exchange. An initial chromosomal analysis of peripheral blood lymphocytes revealed abnormal patterns of 45, XO/46, XX/47, XXX; a second analysis showed 45, XO/46, XX/47, XXX/47, XX + 21, and a third...

journal_title：Acta haematologica

authors： Itoh Y,Taniguchi T,Takeyama N,Kuriki H,Tanaka T

更新日期：1990-01-01 00:00:00

abstract：:Recent molecular biological investigations have shown that genetic information on the short arm of chromosome 17 is frequently deleted or inactivated in acute myeloid leukaemias and a number of solid tumours. In earlier studies we have found clonal occurrence of a 17p deletion (17p-) in patients with refractory anaemi...

journal_title：Acta haematologica

authors： Pedersen B,Kerndrup G

更新日期：1990-01-01 00:00:00

abstract：:Cardiac scintigraphy has been performed in 60 beta-thalassaemia major patients aged 8-35 years who received regular blood transfusions and subcutaneous desferrioxamine (DFX) chelation. Fifty-seven showed no clinical, radiological or electrocardiographic evidence of heart disease and 3 had clinically apparent cardiac f...

journal_title：Acta haematologica

authors： Aldouri MA,Wonke B,Hoffbrand AV,Flynn DM,Ward SE,Agnew JE,Hilson AJ

更新日期：1990-01-01 00:00:00

abstract：:The immunological phenotypes of lymphocytes and myeloma cells in 48 patients with multiple myeloma (MM) were analyzed using a panel of monoclonal antibodies (mAbs). Myeloma cells were positive for OKT10, BL3, PCA1 and BA2. In a few cases, they were also positive for the B cell-associated antigens J5, B1 and I2. Eight ...

journal_title：Acta haematologica

authors： Shimazaki C,Fried J,Perez AG,Scheinberg DA,Atzpodien J,Wang CY,Wisniewolski R,Clarkson BD

更新日期：1990-01-01 00:00:00

abstract：:Hypersensitivity vasculitis occurs in response to various exogenous agents. A case of a serum sickness syndrome with cutaneous vasculitis is described in a patient given an intravenous iron-dextran infusion. ...

journal_title：Acta haematologica

authors： Bielory L

更新日期：1990-01-01 00:00:00

abstract：:A 67-year-old woman with agnogenic myeloid metaplasia, who underwent splenectomy 1 year after the diagnosis, experienced spontaneous hematologic remission 6 years after splenectomy. Ten months before her anemia improved, peripheral leukocytes no longer showed a shift to the left and peripheral erythroblasts had disapp...

journal_title：Acta haematologica

authors： Shimizu K,Hotta T

更新日期：1990-01-01 00:00:00

abstract：:We describe in this paper a female patient affected by chronic granulomatous disease with all the features of the classic X-linked form of the disease and presenting a mild form of the disease, the major clinical manifestation being a granulomatous cheilitis. The capability of the patient's phagocytes to undergo a res...

journal_title：Acta haematologica

authors： Dusi S,Poli G,Berton G,Catalano P,Fornasa CV,Peserico A

更新日期：1990-01-01 00:00:00

abstract：:The case history of a 71-year-old woman with three episodes of a microangiopathic hemolytic anemia over a 22-year span is detailed. During the last episode a possible response of her thrombotic thrombocytopenic purpura (TTP)-like syndrome to the administration of intravenous immunoglobulin is documented. In retrospect...

journal_title：Acta haematologica

authors： Staszewski H,Colbourn D,Donovan V,Ludman H

更新日期：1989-01-01 00:00:00

abstract：:In order to study the abnormal differentiation and proliferation of precursor T cells in homosexual men, a study was made of T-cell colony formation in 15 healthy homosexual men without anti-human immunodeficiency virus (HIV) antibody. The colony forming method used was the one-step monolayer technique using phytohema...

journal_title：Acta haematologica

authors： Wakabayashi Y,Sugimoto M,Ishiyama T,Hashimoto M,Horie S,Hirose S

更新日期：1989-01-01 00:00:00

abstract：:The short-term effect of a domestically produced equine antithymocyte globulin (ATG) was analyzed in 6 patients with acquired severe aplastic anemia (AA). All patients received 5 doses of ATG every other day in a 60-min intravenous infusion. Five peripheral blood immunoregulatory mononuclear cell (MNC) subsets, define...

journal_title：Acta haematologica

authors： López-Karpovitch X,Zarzosa ME,Cárdenas MR,Piedras J

更新日期：1989-01-01 00:00:00

abstract：:A 44-year-old Japanese male having refractory anemia with excess of blasts (RAEB) preceding acute myelomonocytic leukemia (AMMoL) with dysplastic marrow eosinophilia (M4Eo in the FAB classification) is reported. Sequential cytogenetic studies revealed a specific chromosomal abnormality, inv(16) (p13q22), when RAEB was...

journal_title：Acta haematologica

authors： Horiike S,Misawa S,Nishida K,Nishigaki H,Tsuda S,Taniwaki M,Takino T,Abe T

更新日期：1989-01-01 00:00:00

abstract：:Glucocorticosteroid hormones have been reported either to stimulate or to inhibit human erythropoiesis. We have studied the in vitro effect of hydrocortisone, 10(-6) mol/l, on human BFU-E when stimulated by preconstituted burst-promoting activity (BPA) in a medium conditioned by T lymphocytes. Hydrocortisone was found...

journal_title：Acta haematologica

authors： Morra L,Ponassi A,Moccia F,Mela GS,Ponassi I,Bessone G

更新日期：1989-01-01 00:00:00

abstract：:A patient with common acute lymphoblastic leukaemia (ALL), hypereosinophilic syndrome and t(5;14) (q31.1;q32.3) translocation is described. Even with intensive treatment only short periods of complete remission were achieved. Recurrence of the leukaemia was always accompanied by the appearance of eosinophilic granuloc...

journal_title：Acta haematologica

authors： Baumgarten E,Wegner RD,Fengler R,Ludwig WD,Schulte-Overberg U,Domeyer C,Schüürmann J,Henze G

更新日期：1989-01-01 00:00:00

abstract：:Pyrimidine 5'-nucleotidase (P5'N) partial deficiency has been described in several hematological disorders and also in the beta-thalassemic trait. To check if the P5'N deficiency in thalassemia was acquired we used thalassemic red cells (from either homo- or heterozygous subjects), whose P5'N activity was lower than i...

journal_title：Acta haematologica

authors： David O,Vota MG,Piga A,Ramenghi U,Bosia A,Pescarmona GP

更新日期：1989-01-01 00:00:00

abstract：:Twenty-four infants and children suffering from glucose-6-phosphate dehydrogenase (G6PD) deficiency during hemolytic crisis were included in this study. Their ages ranged between 3 and 36 months with a median of 10 months. 22 were males and 2 were females. Fourteen out of them received a single bolus dose of desferrio...

journal_title：Acta haematologica

authors： Khalifa AS,el-Alfy MS,Mokhtar G,Fakeir AA,Khazbak MA,el-Baz F,el-Kholy M

更新日期：1989-01-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is thought to take part in the genesis of bone marrow fibrosis that can be found in patients with myeloproliferative diseases. We evaluated platelet mitogenic activity as the difference between serum and plasma activity in 8 patients with myeloproliferative disease. We observed a ...

journal_title：Acta haematologica

authors： Caenazzo A,Pietrogrande F,Polato G,Piva E,Masiero M,Sgarabotto D,Girolami A

更新日期：1989-01-01 00:00:00

abstract：:Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than sample...

journal_title：Acta haematologica

authors： Okajima K,Koga S,Okabe H,Inoue M,Takatsuki K

更新日期：1989-01-01 00:00:00

abstract：:We studied neutrophil chemotaxis and surface membrane glycoproteins in 12 patients suffering from myeloid disorders with abnormal karyotype using in vitro techniques in all 12. Chromosome studies were also carried out virtually simultaneously. We chose to study only patients showing a deficit of chemotaxis (p less tha...

journal_title：Acta haematologica

authors： Ricevuti G,Mazzone A,Notario A

更新日期：1989-01-01 00:00:00

abstract：:In evaluating hypoimmunoglobulinemia in a patient with nonsecretory myeloma, studies of in vitro immunoglobulin synthesis were performed during a 3-year period. Impaired polyclonal response to mitogen stimulation associated with excessive suppressor activity was demonstrable at diagnosis. Despite successful chemothera...

journal_title：Acta haematologica

authors： Shustik C,Michel R,Karsh J

更新日期：1988-01-01 00:00:00

abstract：:A 13-year-old Saudi girl presented with severe clinical features of systemic lupus erythematosus of 3 months' duration. In addition to laboratory evidence of the disease, the patient was found to have pancytopenia and myelofibrosis. While pancytopenia was considerably improved by steroids, myelofibrosis was not revers...

journal_title：Acta haematologica

authors： el Mouzan MI,Ahmad MA,al Fadel Saleh M,al Sohaibani MO,al Gindan YM

更新日期：1988-01-01 00:00:00

abstract：:In a group of 56 patients with acute leukaemia, the relation between leukaemic cell motility and peripheral leukaemic cell count, degree of organomegaly, maturation and FAB classification was investigated. Cell motility was studied by means of directly observed motility and scoring of handmirror cells and anti-HLA-cap...

journal_title：Acta haematologica

authors： van der Weide M,Imandt LM,Langenhuijsen MM

更新日期：1988-01-01 00:00:00

abstract：:A 69-year-old woman presented with chronic lymphocytic leukemia (CLL) diagnosed after bone marrow recovery following intensive chemotherapy for acute lymphoblastic leukemia. The retrospective diagnosis of initial blastic transformation of CLL was made. The patient eventually died, 5 months after initial blastic phase,...

journal_title：Acta haematologica

authors： Archimbaud E,Charrin C,Gentilhomme O,Rimokh R,Guyotat D,Fiere D,Germain D

更新日期：1988-01-01 00:00:00

abstract：:The plasma cortisol levels of 108 children aged 1-16 years with various Hb genotypes (AA, AS and SS) were measured. The mean plasma cortisol levels of both the AS and SS groups (during steady state) fell within the normal range but the mean of the SS group is significantly lower than the AA group. In fact, 9 of the si...

journal_title：Acta haematologica

authors： Osifo BO,Lukanmbi FA,Adekile A

更新日期：1988-01-01 00:00:00

abstract：:Using enzyme-linked immunosorbent assay (ELISA) and confirmatory immunoprecipitation tests, sera from 640 Nigerians from Lagos and Cross River States were examined for antibodies against HIV. These comprised 570 blood donors and their family members, 56 patients with various haematological conditions and 14 patients w...

journal_title：Acta haematologica

authors： Okpara RA,Akinsete I,Williams EE,Schneider J,Wendler I,Hunsmann G

更新日期：1988-01-01 00:00:00

abstract：:Dihydrofolate reductase (FH2-R) was studied cytochemically in the bone marrow erythroblasts of 20 normal controls and 46 patients with myelodysplastic syndromes (MDSs) classified according to FAB, prior to therapy. The reaction product was quantified for the same samples with a Vickers M86 microdensitometer. The enzym...

journal_title：Acta haematologica

authors： Nano R,Invernizzi R,Rezzani R,Gerzeli G

更新日期：1988-01-01 00:00:00

abstract：:The in vitro immune functions of peripheral blood lymphocytes have been studied in 12 children with beta-thalassaemia major and hypersplenism. The study was performed prior to splenectomy and on the 2nd, 6th, 15th and 30th day after splenectomy. It was found that before splenectomy, patients had low numbers of blood l...

journal_title：Acta haematologica

authors： Mandalenaki-Lambrou K,Vrachnou E,Calogeropoulou C,Ladis V,Kattamis C

更新日期：1987-01-01 00:00:00

abstract：:At our hospital, 47 out of 184 consecutive splenectomies performed over 7 recent years were carried out on patients afflicted with various hematologic diseases. The results of these 47 splenectomies were the subject of a careful retrospective analysis. The majority of the splenectomies (81%) were therapeutic. Cytopeni...

journal_title：Acta haematologica

authors： Dotevall A,Kutti J,Wadenvik H,Westin J,Angerås U,Darle N

更新日期：1987-01-01 00:00:00

abstract：:Sera from 154 hemophiliacs, including 132 with hemophilia A and 22 with hemophilia B, were examined for antibodies against human T cell lymphotropic virus type III (HTLV-III) and type I by strip radioimmunoassay based on the Western blotting technique. Sixty-two patients lived in Kyushu, a known endemic area of HTLV-I...

journal_title：Acta haematologica

authors： Hattori T,Ikematsu S,Chosa T,Yamamoto S,Matsuoka M,Fukutake K,Robert-Guroff M,Takatsuki K

更新日期：1987-01-01 00:00:00

abstract：:This paper reports the bone marrow histological picture in 7 patients with hairy cell leukemia treated with recombinant interferon. Bone marrow biopsies were performed at diagnosis, after 1, 3 and 7 months from the beginning of treatment and at 12 months at treatment suspension. The main modifications observed were a ...

journal_title：Acta haematologica

authors： Lambertenghi-Deliliers G,Benazzi E,Cortelezzi A,Polli EE

更新日期：1987-01-01 00:00:00

abstract：:The presence of the sickle cell (Hb S) gene in Saudi Arabia was first reported by Lehmann et al. in 1963 [Nature 198, pp. 492-493]. Later, Hb S, alpha- and beta-thalassaemia, glucose-6-phosphate dehydrogenase deficiency and other enzymopathies were shown to occur at a variable prevalence in different regions of the co...

journal_title：Acta haematologica

authors： el-Hazmi MA

更新日期：1987-01-01 00:00:00

abstract：:The course and management of avascular necrosis of the femoral head (AVNFH) in six hips of 5 sickle cell syndrome patients (3 with Hb SS, 1 with Hb SC and 1 with Hb S/beta+-thalassaemia) are described. Two patients (aged 13 and 17 years) presented with Perthes- and osteochondritis dessicans-type lesions. These hips pr...

journal_title：Acta haematologica

authors： Rand C,Pearson TC,Heatley FW

更新日期：1987-01-01 00:00:00

abstract：:Human beta-globin was produced in Escherichia coli as a cleavable fusion protein using the expression vector pLcII [Nagai and Thøgersen, Nature 301, p. 810, 1984]. The fusion protein CIIFX beta-globin was purified under denaturing conditions to homogeneity and the authentic beta-globin was liberated by blood coagulati...

journal_title：Acta haematologica

authors： Luisi BF,Nagai K,Perutz MF

更新日期：1987-01-01 00:00:00